Thermo Fisher Scientific uPAR (CD87) Polyclonal Antibody
Thermo Fisher Scientific의 uPAR (CD87) 폴리클로날 항체는 마우스 및 랫트 시료에 반응하며, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 세포 표면 플라스미노겐 활성 조절 연구에 유용합니다. -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived rat uPA Receptor recombinant protein (Position: L25–R261) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746941 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kDa in monocytes, anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) is associated with the carbohydrate-binding domain of SELL in neutrophil membranes, analogous to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. Increased UPAR expression correlates with recurrence and mortality rates, making UPAR a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보: PA5-79826_uPAR_CD87_P49616-1_Rabbit.svg, PA5-79826_uPAR_CD87_P49616-1_Rabbit_PDP.jpeg)
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