Thermo Fisher Scientific PKP2 Polyclonal Antibody
PKP2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 IHC(Paraffin) 검증 완료. 인간과 마우스 반응성. 액상 형태, 0.5 mg/mL 농도, -20°C 보관. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RGTAQYSSQKSVEER |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933367 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms (NP_001005242.2; NP_004563.2).
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Plakophilins (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments.
They contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes—cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress.
Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
Plakophilin 4 regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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