Thermo Fisher Scientific CD38 Monoclonal Antibody (4G3)
CD38 단백질을 표적하는 Mouse IgG1 단클론 항체로, Human 시료에 반응합니다. Western blot, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Affinity chromatography로 정제된 액상 형태이며, 보존제 없이 PBS buffer에 저장됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G3 |
| Immunogen | CD38 (AAH07964, 201–300 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA WVIHGGREDS RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI
Target Information
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful for subtyping lymphomas and leukemias, detecting plasma cells (e.g., identification of myelomas), and as markers for activated B and T cells.
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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