Thermo Fisher Scientific CD40 Monoclonal Antibody (1G1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein Sequence:
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHFHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIDICQPH FPKDRGLNLL M

Target Information

The CD40 antigen is a single chain glycoprotein belonging to the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells, as well as on some epithelial cells, carcinomas, and lymphoid dendritic cells.

CD40 plays a crucial role in immune and inflammatory responses, including:

• T cell-dependent immunoglobulin class switching
• Memory B cell development
• Germinal center formation

AT-hook transcription factor AKNA regulates CD40 expression, facilitating homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 to mediate signal transduction. The CD40–ligand interaction is essential for amyloid-beta-induced microglial activation, implicated in early Alzheimer’s disease pathogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

Associated Diseases:
Type 3 Hyper-IgM immunodeficiency, CD40 ligand deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.