Thermo Fisher Scientific GNAS Monoclonal Antibody (A8F11)
GNAS 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(A8F11). Western blot, IHC, ICC 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 시료에 반응. Protein A로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적 유지 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8F11 |
| Immunogen | Recombinant protein within human GNAS aa 2–251 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931376 |
Target Information
Mutations in the GNAS gene are associated with a variety of disorders, including pseudohypoparathyroidism type 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and certain pituitary tumors.
The gene exhibits complex imprinted expression, producing maternally, paternally, and biallelically expressed proteins from alternatively spliced transcripts with distinct 5’ exons. Some transcripts introduce frameshifts, resulting in structurally unrelated isoforms. An antisense transcript may also regulate imprinting in this region.
Mutations can lead to pseudohypoparathyroidism type 1a (PHP1a), which follows an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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