Thermo Fisher Scientific p53 Monoclonal Antibody (OTI7C5), TrueMAB
p53 단백질을 인식하는 마우스 단일클론 항체로, Western blot에 최적화되어 있습니다. 인간 시료에 반응하며, TrueMAB 형식으로 높은 특이성과 재현성을 제공합니다. 세포 스트레스 반응 연구 및 암 관련 단백질 분석에 적합합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C5 |
| Immunogen | Full length human recombinant protein of human TP53 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 activation leads to transcription of genes such as p21waf1, influencing G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. Phosphorylation at Ser15 is crucial for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 is typically low in normal cells but elevated in transformed cell lines, contributing to malignancy. Mutations in TP53 can result in loss of tumor-suppressor function and are found in various cancers, including hereditary forms like Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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