Thermo Fisher Scientific p53 Monoclonal Antibody (OTI4C10), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. p53 activation leads to transcription of genes such as p21waf1 involved in G1 or G2/M arrest. Structurally, p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is critical for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and functions as an anticancer agent. It is also linked to aging, oxidative stress, and memory deficits. Normally expressed at low levels, p53 is upregulated in transformed cells, contributing to malignancy. Mutations in TP53 lead to loss of tumor suppressor activity and are found in various cancers and hereditary cancer syndromes such as Li-Fraumeni.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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