Thermo Fisher Scientific Cerebral Protein 1 Polyclonal Antibody
Cerebral Protein 1을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며, 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 100–200 of human RRP8 (NP_056139.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.104 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914323 |
Product Specific Information
- Positive test controls include: Mouse kidney, Mouse spleen, Rat kidney, Rat thymus.
- Immunogen sequence:
GPPCSDSEEE VERKKKCHKQ ALVGSDSAED EKRKRKCQKH APINSAQHLD NVDQTGPKAW KGSTTNDPPK QSPGSTSPKP PHTLSRKQWR NRQKNKRRCK N
Target Information
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to intracellular energy status by recruiting histone-modifying enzymes.
Upon glucose starvation, the elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and formation of silent chromatin at the rDNA locus.
In this complex, RRP8 binds to H3K9me2 and likely acts as a methyltransferase, though its substrates remain unknown.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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