Thermo Fisher Scientific SARM Polyclonal Antibody
SARM1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, ELISA, Immunoprecipitation에 적합. 고순도 Affinity Chromatography 정제, 인간 반응성, 액상 형태로 안정적 보관 가능.
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Thermo Fisher Scientific SARM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 625–724 of human SARM1 (NP_055892.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.09 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914322 |
Product Specific Information
- Positive test controls include: 293T, SH-SY5Y
- Immunogen sequence:
ALDKCMQDHD CKDWVHKEIV TALSCGKNIV PIIDGFEWPE PQVLPEDMQA VLTFNGIKWS HEYQEATIEK IIRFLQGRSS RDSSAGSDTS LEGAAPMGPT
Target Information
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathways by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death involving axonal degradation distal to the injury site. SARM1 activation catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR), and nicotinamide, leading to cytoskeletal degradation and axon destruction. Also hydrolyzes NADP(+), regulates neuronal cell death under stress, and modulates dendritic arborization via MAPK4-JNK pathway. Involved in innate immune response by inhibiting activation of JUN/AP-1, NF-κB, IRF3, and MAPK14/p38. [UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-120750_SARM_Q6SZW1-1_Rabbit.svg, PA5-120750_SARM_Q6SZW1-1_Rabbit_PDP.jpeg)
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