Thermo Fisher Scientific CCBL1 Polyclonal Antibody
CCBL1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체. Western blot과 IHC(파라핀 절편)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length fusion protein of human CCBL1 (aa 1–422, UniProt ID: Q16773-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636760 |
Product Specific Information
This antibody detects endogenous levels of total CCBL1 protein.
Target Information
Kynurenine aminotransferases (KAT I, KAT II, and KAT III) belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic enzyme involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective metabolite of tryptophan.
Kynurenic acid plays a role in synaptic transmission and has been implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also participates in the metabolism of cysteine conjugates of halogenated compounds, forming reactive intermediates.
Three isoforms of KAT I are known:
- Isoform 1: full-length protein
- Isoform 2: lacks amino acids 68–117
- Isoform 3: lacks amino acids 251–422
Based on sequence similarity, KAT I functions as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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