Thermo Fisher Scientific ESX1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:2,500–1:5,000

Immunocytochemistry (ICC/IF)

• Tested Concentration: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
HEPEQQQEEP PLLELKQEQE EPPQTTVEGP QPAEGPQTAE GPQPPERKRR RRTAFTQFQ

Antigen sequence identity:

• Mouse: 37%
• Rat: 36%

Target Information

Homeobox proteins are transcription factors containing a helix-turn-helix DNA binding domain called the homeodomain.
ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis, with two functional domains: the homeodomain and a proline-rich domain.
During embryogenesis, ESX1 is expressed in extraembryonic tissues, including the endoderm of the visceral yolk sac, ectoderm of the chorion, and labyrinthine trophoblast of the chorioallantoic placenta.
ESX1 can act as a transcriptional repressor to the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces tumorigenicity in cells with oncogenic K-ras mutations, suggesting potential therapeutic relevance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.