Thermo Fisher Scientific Human TAB3 Synthetic Peptide
인간 TAB3 단백질의 N-말단 부위에 해당하는 13 아미노산 합성 펩타이드. NF-κB 신호전달 연구용 차단 펩타이드로 사용 가능. PBS(pH 7.2)와 0.1% BSA 내 액상 형태로 제공. -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 13 amino acid sequence near the amino terminus of human TAB3.
PEP-1409 can be used as a blocking peptide with polyclonal antibody PA5-34366.
Target Information
TAB3 functions in the NF-kappaB signal transduction pathway. It, along with the similar and functionally redundant protein TAB2, forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.
Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1. Upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as control points for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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