Thermo Fisher Scientific Human TAB2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 14 amino acid sequence near the carboxy terminus of human TAB2.
PEP-1408 can be used as a blocking peptide with the polyclonal antibody PA5-34365.

Target Information

TAB2 is an activator of MAP3K7/TAK1, required for IL-1 induced activation of NF-kappaB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, acting as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL-induced signal transduction through activation of TNFRSF11A/RANK, potentially regulating osteoclast development and function.
Recent studies show that TAB2 and TAB3 interact with the autophagy mediator Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while depletion triggers it, suggesting their role as control points for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.