Thermo Fisher Scientific SULT2A1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, less than 2% cross-reactivity with recombinant human SULT1A1, SULT1A3, SULT1B1, SULT1E1, and SULT4A1 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds.
SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids, and bile acids, and is highly expressed in adrenal and liver tissues. It plays a role in hepatic cholesterol homeostasis.
SULT2B1 consists of two isoforms, SULT2B1a and SULT2B1b, which are transcribed from the same gene by alternative splicing. Both isoforms are highly selective for the sulphation of 3β-hydroxysteroids such as pregnenolone, epiandrosterone, DHEA, and androstenediol. SULT2B1b is expressed in prostate, skin, placenta, and lung.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.