Thermo Fisher Scientific CCL4 Polyclonal Antibody
개 및 관련 종에서 CCL4 단백질을 검출하는 Sheep polyclonal antibody. Western blot 및 Immunocytochemistry에 최적화. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose buffer에 동결건조 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant canine CCL4/MIP-1 beta (Ala24–Asn92) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607322 |
Product Specific Information
- In direct ELISAs, approximately 10% cross-reactivity with recombinant human CCL4/MIP-1 beta and recombinant mouse CCL4/MIP-1 beta is observed.
- Less than 1% cross-reactivity with recombinant viral CCL4/MIP-1 beta is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory responses and homeostasis. It is produced by macrophages upon stimulation by bacterial endotoxins and recruits various inflammatory cells to sites of inflammation.
CCL4 is expressed by lymphocytes, macrophages, and dendritic cells. Together with CCL3, it participates in host defense against bacterial, viral, parasitic, and fungal pathogens by regulating trafficking and activation of specific inflammatory cell subgroups.
While both CCL4 and CCL3 affect monocytes similarly, they differ in lymphocyte specificity:
- CCL4 selectively attracts CD4+ lymphocytes
- CCL3 selectively attracts CD8+ lymphocytes
Both act as potent chemoattractants for B cells, eosinophils, and dendritic cells. The processed form of CCL4 can down-regulate CCR5 receptor expression, thereby inhibiting CCR5-mediated HIV-1 entry into T cells. CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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