Thermo Fisher Scientific NR0B2 Monoclonal Antibody (OTI7B5), TrueMAB
NR0B2 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. 인간 시료에 반응하며, 고순도 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 안정적 보관을 위해 -20°C에서 보관 권장.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B5 |
| Immunogen | Full length human recombinant protein of human NR0B2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the NR0B2 gene is an orphan nuclear receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. It belongs to the nuclear hormone receptor family, which includes transcription factors regulated by small hydrophobic hormones. This protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. It also interacts with estrogen receptors, leading to inhibition of their function. Studies suggest that NR0B2 represses nuclear hormone receptor-mediated transactivation through competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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