Thermo Fisher Scientific ALDH5A1 Polyclonal Antibody
ALDH5A1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원 사용. 연구용으로만 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TGKILLHHAANS) corresponding to the internal amino acids of ALDH5A1 (aa 288–299) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984405 |
Product Specific Information
- This antibody is predicted to react with bovine and canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. These enzymes play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.
Aldh5A1 functions as a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. Deficiency of this enzyme, known as 4-hydroxybutyricaciduria, leads to a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms typically include static encephalopathy, developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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