Thermo Fisher Scientific AKAP3 Polyclonal Antibody
AKAP3 단백질을 특이적으로 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, Affinity chromatography로 정제된 1 mg/mL 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AKAP3 (Accession O75969), corresponding to amino acid residues G199–R249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818190 |
Product Specific Information
Antibody detects endogenous levels of total AKAP3.
Target Information
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this localization, the R subunit (RII) of PKA interacts with RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP).
AKAP3 (also known as AKAP110, FSP95, PRKA3, SOB1) binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP3 in normal tissues is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP3, increasing its recruitment of PKA. AKAP3 also shows high expression in epithelial ovarian cancer (EOC), with tumor-restricted expression and correlation to worse overall survival, suggesting it as a potential target for antigen-specific immunotherapy in EOC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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