Thermo Fisher Scientific SATB1 (Marker of Lymph Node Metastasis of CRC) Monoclonal Antibody (PCRP-SATB1-2C3)
인간 SATB1 단백질을 인식하는 마우스 모노클론 항체로, 림프절 전이 표지자 연구에 적합. ICC/IF 및 Flow Cytometry에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-SATB1-2C3 |
| Immunogen | Recombinant full-length human SATB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: HeLa cells
- Cellular Location: Nucleus
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to DNA at AT-rich sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA. SATB1 acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner, influencing chromatin-loop remodeling. It modulates genes essential for T-cell maturation (CD8SP thymocytes). SATB1-binding sites create a chromatin context targeted by HIV-1 integration machinery, and HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA by competing for HDAC1 binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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