Thermo Fisher Scientific VEGF Monoclonal Antibody (VG1)
VEGF 단백질을 인식하는 VG1 클론 단일클론 항체로, 인간·마우스 등 다양한 종에 반응합니다. Western blot, IHC, ICC, Flow cytometry 등 다중 응용이 가능하며, 혈관신생 관련 연구에 적합합니다. 단백질 G 정제, 액상 형태, 1 mg/mL 농도.
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Thermo Fisher Scientific VEGF Monoclonal Antibody (VG1)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 17 publications |
| Immunohistochemistry (IHC) | – | View 52 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:100 | View 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20–1:100 | – |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 | View 3 publications |
| Flow Cytometry (Flow) | Assay-Dependent | – |
| ELISA | Assay-Dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Pig, Rat |
| Published Species | Camelid, Human, Mouse, Rabbit, Rat |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VG1 |
| Immunogen | Recombinant VEGF protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at –20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2212682 |
Product Specific Information
- For IHC, incubate for 30–60 minutes at room temperature.
- High-temperature treatment of formalin-fixed tissue sections using 1 mM EDTA, pH 8.0 must be performed prior to immunostaining.
Target Information
VEGF (vascular endothelial growth factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis, promoting tumor progression and metastasis. It enhances endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability.
The VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system are fundamental regulators of angiogenesis signaling. Most tumors require angiogenesis, and VEGF is a potent angiogenic cytokine associated with this process.
Five isoforms of VEGF arise from alternative splicing of a single gene, binding to tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), expressed mainly on endothelial cells. The soluble form sFLT1 binds VEGF with high affinity, inhibiting angiogenesis.
Elevated VEGF levels are linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes), also known as Crow-Fukase syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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