Thermo Fisher Scientific Desmoglein 4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 480-630 of human DSG4 (NP_8171231) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Desmoglein 4,uniProtId:Q86SJ6-1,ncbiNodeId:9606,antigenRange:480-630,antigenLength:1040,antigenImageFileName:PA5-87952_Desmoglein_4_Q86SJ6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87952_Desmoglein_4_Q86SJ6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.78 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804534

Product Specific Information

Immunogen sequence: TGTICIEVPD INDYCPNIFP ERRTICIDSP SVLISVNEHS YGSPFTFCVV DEPPGIADMW DVRSTNATSA ILTAKQVLSP GFYEIPILVK DSYNRACELA QMVQLYACDC DDNHMCLDSG AAGIYTEDIT GDTYGPVTED QAGVSNVGLG P; Positive Samples: Mouse pancreas, Rat pancreas, A-375, DU145, BxPC-3, Mouse pancreas, Mouse small intestine; Cellular Location: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome

Target Information

Desmoglein proteins are cadherin-type cell adhesion molecules. Desmoglein 4 (dsg4) shares 41% identity with human desmoglein 1, 37% with human desmoglein 2 and 50% with human desmoglein 3. A type I membrane protein of the cadherin protein family, dsg4 is expressed in salivary gland, suprabasal epidermis, hair follicle, testis, prostate and skin. In the hair follicle, dsg4 is an important mediator of keratinocyte cell adhesion and coordinates the transition from proliferation to differentiation. The human DSG4 gene is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.