Thermo Fisher Scientific Desmoglein 4 Polyclonal Antibody
Desmoglein 4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity 정제 항체입니다. 세포막 및 데스모좀 단백질 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 480–630 of human DSG4 (NP_8171231) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.78 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804534 |
Product Specific Information
Immunogen sequence:
TGTICIEVPD INDYCPNIFP ERRTICIDSP SVLISVNEHS YGSPFTFCVV DEPPGIADMW DVRSTNATSA ILTAKQVLSP GFYEIPILVK DSYNRACELA QMVQLYACDC DDNHMCLDSG AAGIYTEDIT GDTYGPVTED QAGVSNVGLG P
Positive Samples:
Mouse pancreas, Rat pancreas, A-375, DU145, BxPC-3, Mouse pancreas, Mouse small intestine
Cellular Location:
Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome
Target Information
Desmoglein proteins are cadherin-type cell adhesion molecules.
Desmoglein 4 (DSG4) shares 41% identity with human desmoglein 1, 37% with desmoglein 2, and 50% with desmoglein 3.
A type I membrane protein of the cadherin family, DSG4 is expressed in salivary gland, suprabasal epidermis, hair follicle, testis, prostate, and skin.
In the hair follicle, DSG4 mediates keratinocyte cell adhesion and regulates the transition from proliferation to differentiation.
The human DSG4 gene spans approximately 37 kb on chromosome 18q12 and is located between DSG1 and DSG3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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