Thermo Fisher Scientific FOXO1A Monoclonal Antibody (1F6)
FOXO1A 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 1F6). Western blot 및 ELISA에 검증됨. 인슐린 신호전달 및 세포사멸 조절 연구에 적합. PBS 용액 형태로 제공되며 보존제 없음.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F6 |
| Immunogen | FOXO1A (NP_002006, 556–655 a.a.) partial recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TQVKTPVQVP LPHPMQMSAL GGYSSVSSCN GYGRMGLLHQ EKLPSDLDGM FIERLDCDME SIIRNDLMDG DTLDFNFDNV LPNQSFPHSV KTTTHSWVSG
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a transcription factor belonging to the forkhead homeotic gene family. It can function as a coactivator or corepressor of nuclear receptor activity mediated through the LXXLL motif.
FOXO1 association with PAX3 has been implicated in alveolar rhabdomyosarcoma. It is linked to anti-tumor activity, autophagy, and myogenic growth and differentiation.
FOXO1 is a major target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) and Daf-16 family binding element (DBE).
FOXO1 regulates redox balance, osteoblast numbers, and bone mass, and modulates endocrine functions related to glucose metabolism. In hepatocytes, it promotes gluconeogenesis by activating genes such as IGFBP1, G6PC, and PPCK1.
FOXO1 acts downstream of CDK1, PKB/AKT1, and SKT4/MST1 as an important regulator of cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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