Thermo Fisher Scientific FOXO1A Monoclonal Antibody (4A3)
FOXO1A 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 4A3). Western blot, ICC/IF, ELISA에 적합하며, Human 반응성. PBS buffer 기반 액상 형태로, 보존제 없음. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A3 |
| Immunogen | Full-length recombinant FOXO1A (NP_002006, ~555 a.a.) with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:msqyncapgl lkelltsdsp phndimtpvd pgvaqpnsrv lgqnvmmgpn svmstygsqa shnkmmnpss hthpghaqqt savngrplph tvstmphtsg mnrl
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a transcription factor belonging to the forkhead homeotic gene family. It can function as both a coactivator and a corepressor of nuclear receptor activity through the LXXLL motif. Association with PAX3 is linked to alveolar rhabdomyosarcoma.
FOXO1 plays a role in autophagy, myogenic differentiation, and tumor suppression. It is a key target of insulin signaling, regulating metabolic homeostasis under oxidative stress.
FOXO1 binds to the insulin response element (IRE) and the Daf-16 family binding element (DBE), acting as a regulator of redox balance, osteoblast numbers, and bone mass. It also modulates glucose metabolism by interacting with RUNX2 and PPARGC1A, activating genes such as IGFBP1, G6PC, and PPCK1.
FOXO1 is an important regulator of cell death downstream of CDK1, PKB/AKT1, and MST1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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