Thermo Fisher Scientific CHRNG Polyclonal Antibody
Rabbit polyclonal antibody targeting human CHRNG for WB and IHC applications. Detects endogenous CHRNG levels. Affinity-purified, unconjugated, supplied in PBS with glycerol. Suitable for research use in neuromuscular studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHRNG (Accession P07510), corresponding to amino acid residues A20–E70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852892 |
Product Specific Information
Antibody detects endogenous levels of total CHRNG.
Target Information
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein composed of two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit.
This gene encodes the gamma subunit, expressed prior to the thirty-third week of gestation in humans. The gamma subunit plays a role in neuromuscular organogenesis and ligand binding.
Disruption of gamma subunit expression prevents proper localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome.
Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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