Thermo Fisher Scientific CHRNG Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CHRNG.

Target Information

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein composed of two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit.
This gene encodes the gamma subunit, expressed prior to the thirty-third week of gestation in humans. The gamma subunit plays a role in neuromuscular organogenesis and ligand binding.
Disruption of gamma subunit expression prevents proper localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome.
Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.