Thermo Fisher Scientific LRWD1 Polyclonal Antibody
Thermo Fisher Scientific의 LRWD1 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 반응. Western blot 및 ELISA에 적합하며, G1/S 전이 및 ORC 복합체 형성 연구에 유용. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보관.
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- PA590566
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–150 of human LRWD1 (NP_690852.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806120 |
Product Specific Information
Immunogen sequence:
QELDLSNNHL ETLPDNLGLS HLRVLRCANN QLGDVTALCQ FPKLEELSLE GNPFLTVNDN LKVSFLLPTL RKVNGKDASS TYSQVENLNR ELTSRVTAHW E
Positive Samples:
U-87MG, HeLa, HepG2, Jurkat, Mouse testis, Mouse thymus, Rat testis
Cellular Location:
Chromosome, Cytoplasm, Nucleus, Centromere, Centrosome, Cytoskeleton, Microtubule organizing center, Telomere
Target Information
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 phase to establish the pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells.
Binds DNA and histone methylation repressive marks on heterochromatin, including H3K9me3, H3K27me3, and H4K20me3, in cooperation with DNA methylation.
Required for silencing of major satellite repeats and may contribute to the stability of ORC2, ORC3, and ORC4.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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