Thermo Fisher Scientific MEPCE Polyclonal Antibody
MEPCE 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 안정적인 액상 형태로 4°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200–250 of human Methylphosphate Capping Enzyme |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
MEPCE is an S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, stabilizing it (PubMed:17643375, 19906723, 30559425).
It also functions as part of the 7SK RNP complex, which sequesters the positive transcription elongation factor b (P-TEFb) to prevent RNA polymerase II phosphorylation and transcriptional elongation.
Additionally, the 7SK RNP complex promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC).
Within the 7SK RNP complex, MEPCE stabilizes 7SK RNA and facilitates complex assembly.
Interaction with LARP7 occludes its catalytic center, conferring a non-enzymatic regulatory function (PubMed:19906723).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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