Thermo Fisher Scientific SGOL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence:
  NSDRPVTRPL AKRALKYTDE KETEGSKPTK TPTTTPPETQ QSPHLSLKDI
• Sequence homology:
  Horse: 91%
  Human: 100%
  Rat: 79%

Target Information

The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
Evidence suggests that this protein also protects a subset of cohesin found along chromosome arms during mitotic prophase.
An isoform lacking exon 6 plays a role in centriole cohesion.
Mutations in this gene are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO).
Fibroblast cells from CAID patients show increased proliferation and senescence.
Pseudogenes of this gene exist on chromosomes 1 and 7.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.