Thermo Fisher Scientific SGOL1 Polyclonal Antibody
SGOL1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 단백질에 100% 반응하며, 합성 펩타이드(C-terminal, aa 395-444)를 면역원으로 사용했습니다. 액상 형태, 0.5 mg/mL 농도, PBS(2% sucrose) 완충액에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human SGOL1 (aa 395–444) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607522 |
Product Specific Information
- Peptide sequence:
NSDRPVTRPL AKRALKYTDE KETEGSKPTK TPTTTPPETQ QSPHLSLKDI - Sequence homology:
Horse: 91%
Human: 100%
Rat: 79%
Target Information
The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
Evidence suggests that this protein also protects a subset of cohesin found along chromosome arms during mitotic prophase.
An isoform lacking exon 6 plays a role in centriole cohesion.
Mutations in this gene are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO).
Fibroblast cells from CAID patients show increased proliferation and senescence.
Pseudogenes of this gene exist on chromosomes 1 and 7.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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