Thermo Fisher Scientific Ankyrin erythroid Polyclonal Antibody
인간, 마우스, 랫트 반응성의 Ankyrin erythroid 폴리클로날 항체. IHC, ICC, ELISA 등 다양한 응용에 적합. Rabbit IgG로 제작되었으며 Protein A로 정제됨. 연구용으로 세포 골격 단백질 연구에 유용.
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- BS-7594R
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Ankyrin erythroid (amino acids 501–600) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ankyrins are a family of proteins that link integral membrane proteins to the underlying spectrin–actin cytoskeleton, playing key roles in cell motility, activation, proliferation, contact, and maintenance of specialized membrane domains. They are composed of three structural domains:
- An amino-terminal domain with multiple ankyrin repeats
- A central spectrin-binding domain
- A carboxy-terminal regulatory domain, which is variable and subject to alternative splicing
Ankyrin 1, the prototype of this family, was first identified in erythrocytes and later found in brain and muscle tissues. Mutations in erythrocytic ankyrin 1 are associated with approximately half of all hereditary spherocytosis cases. Various isoforms and truncated muscle-specific variants have been identified due to alternative promoter usage and splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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