Thermo Fisher Scientific SMO Polyclonal Antibody
SMO 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 고순도 Affinity chromatography로 정제된 액상 제품입니다.
- 카탈로그번호
- PA5104390
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMO (Accession Q99835), corresponding to amino acid residues N76–L126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853697 |
Product Specific Information
Antibody detects endogenous levels of total SMO.
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It contains seven transmembrane domains, four glycosylation sites, and a putative extracellular amino terminus. Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Shh (Sonic hedgehog gene product) and is a positive regulator of the hedgehog signaling pathway along with the patched protein (PTCH). It regulates vertebrate developmental processes, cellular proliferation, and differentiation by activating transcription factor Gli. Mutations in Smoothened are known to cause sporadic basal cell carcinoma of the skin. Expression is widespread in heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항체의 항원 구조 이미지: PA5-104390_SMO_Q99835-1_Rabbit.svg, PA5-104390_SMO_Q99835-1_Rabbit_PDP.jpeg)
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