Thermo Fisher Scientific UGT1A6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 122-199. Recombinant protein control fragment (Product #RP-110132). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UGT1A6,uniProtId:P19224-1,ncbiNodeId:9606,antigenRange:122-199,antigenLength:532,antigenImageFileName:PA5-144859_UGT1A6_P19224-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144859_UGT1A6_P19224-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092074

Product Specific Information

Immunogen sequence: YFINCQSLLQ DRDTLNFFKE SKFDALFTDP ALPCGVILAE YLGLPSVYLF RGFPCSLEHT FSRSPDPVSY IPRCYTKF

Antigen sequence identity: Mouse 77%; Rat 74%

Target Information

UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.