Thermo Fisher Scientific POLR3H Monoclonal Antibody (OTI4D8)
POLR3H 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체로, Western blot 및 IHC(P) 실험에 적합. 인간 종에 반응하며 비결합형 액상 형태로 제공. 고순도 친화 크로마토그래피 정제 및 안정적인 저장 조건 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D8 |
| Immunogen | Full length human recombinant protein of POLR3H produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723499 |
Target Information
RPC8 is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a specific peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
RPC8 plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in innate immune response, capable of detecting non-self dsDNA that serves as a template for transcription into dsRNA.
Non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-Kappa-B activation through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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