Thermo Fisher Scientific CaV2.1 Polyclonal Antibody

Thermo Fisher Scientific CaV2.1 Polyclonal Antibody

제품 사양

제품 정보

Immunogen sequence:
KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGI

Antigen sequence identity:
Mouse – 100%
Rat – 100%

타깃 정보

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells and are involved in various calcium-dependent processes such as muscle contraction, hormone or neurotransmitter release, and gene expression.
These channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit forms the pore and determines channel activity, while auxiliary subunits regulate this function.
The calcium channel types differ mainly by expression of alpha-1 isoforms (A, B, C, D, E, S). The CACNA1A gene encodes the alpha-1A subunit, predominantly expressed in neuronal tissue. Mutations are associated with familial hemiplegic migraine and episodic ataxia type 2.
Polymorphic variation due to n-repeats occurs; some transcript variants include a polyglutamine tract, and expansion of these repeats (from normal 4–16 to 21–28) is linked to spinocerebellar ataxia type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.