Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
Rabbit polyclonal antibody targeting NMDAR2B, validated for WB, IHC(P), and ICC/IF. Reacts with mouse and rat, concentrated liquid form. Useful for studies on NMDA receptor function, synaptic plasticity, and neurological disorders.
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Applications and Tested Dilutions
| Application | Tested Dilution Range |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of rat NMDAR2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.44 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792772 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Bovine (100%).
- Positive Control: Mouse hippocampus.
- Centrifuge briefly prior to opening the vial.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to memory and learning.
NMDAR plays a role in neuronal development and is implicated in several central nervous system disorders, including Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is linked to enhanced learning and memory, while reduced NR2B expression is observed in aged or memory-impaired subjects. Phosphorylation of Tyr1472 on NR2B may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-85632_NMDAR2B_Q00960-1_Rabbit.svg, PA5-85632_NMDAR2B_Q00960-1_Rabbit_PDP.jpeg)
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