Thermo Fisher Scientific NAB2 Monoclonal Antibody (4H6)
NAB2 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot 및 ELISA에 최적화되어 있습니다. 인체 유래 NAB2 단백질에 반응하며, PBS 버퍼 내 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H6 |
| Immunogen | NAB2 (NP_005958.1, 421–525 a.a.) partial recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ
Target Information
Transcriptional control is partially regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins NAB1 and NAB2. These conserved NAB proteins act as corepressors of EGF-1/NGFI-A.
NAB2 contains two conserved domains:
- NCB1 (NAB conserved domain 1): required for NGFI-A binding
- NCD2 domain: responsible for repressor function
NAB2 is localized in the nucleus and may play a role in NGFI-A downregulation, cell division, differentiation, and apoptosis. It has a predicted molecular mass of 56 kDa and maps to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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