Thermo Fisher Scientific p16INK4a Polyclonal Antibody
p16INK4a 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF, Flow cytometry에 적합. Human 및 Mouse 반응성. 세포주 및 조직 샘플에서 p16INK4a 발현 검출에 유용하며, 세포주기 조절 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
| Flow Cytometry (Flow) | 1:50–1:100 | 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human aa DKN2A 1–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913285 |
Product Specific Information
- Positive Control: Mouse brain tissue lysates, JAR, MCF-7, mouse placenta tissue, mouse colon tissue, mouse brain tissue, 293
- Subcellular Location: Cytoplasm, Nucleus
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase.
The remaining transcript includes an alternate first exon located 20 Kb upstream, encoding an alternate open reading frame (ARF) that specifies a structurally unrelated protein. This ARF product functions as a stabilizer of the tumor suppressor protein p53 by interacting with and sequestering MDM2, the E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, the CDK inhibitor isoforms and the ARF product share a common role in cell cycle G1 control through regulation of CDK4 and p53.
This gene is frequently mutated or deleted in a wide variety of tumors and is recognized as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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