Thermo Fisher Scientific A20 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human A20 (TNFAIP3) protein. Validated for WB and IP applications. Purified by antigen affinity chromatography. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human zinc finger protein A20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several non-Hodgkin lymphoma subtypes. TNFAIP3 encodes a zinc-finger protein induced by TNF-α that inhibits NF-κB-dependent gene expression and protects cells from TNF-α cytotoxicity. Overexpression inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses. At least two isoforms of TNFAIP3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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