Thermo Fisher Scientific A20 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human A20 (TNFAIP3) protein. Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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- A302633Ax (2개 옵션)
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific A20 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human zinc finger protein A20 (TNFAIP3, UniProt ID: P21580-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It has been identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 encodes a zinc-finger protein that is rapidly and transiently induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting its role as a negative regulator of TLR-mediated inflammatory responses and protection against excessive immune responses. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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