Thermo Fisher Scientific GSTM1 Monoclonal Antibody (524CT17.2.5)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds such as carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress through conjugation with glutathione.
The mu class genes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic. These variations may affect susceptibility to toxins and carcinogens, as well as drug efficacy. Null mutations have been linked to increased cancer risk due to heightened sensitivity to environmental toxins. Multiple isoforms are encoded by transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.