Thermo Fisher Scientific CRMP1 Polyclonal Antibody
CRMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합. Human 및 Mouse 반응성 검증. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 고농도(0.99 mg/mL)로 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:50,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 34–305 of CRMP1 (Uniprot ID: Q14194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.99 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2552120 |
Product Specific Information
- Recommended positive controls: HepG2, mouse brain
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (87%), Chicken (93%), Rhesus Monkey (98%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, playing major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in regions of high synaptic remodeling (e.g., cerebellum, hippocampus, olfactory system) suggests involvement in adult brain plasticity.
CRMP-1, initially identified as a dihydro-pyrimidinase expressed exclusively in brain, is involved in neurotrophin (NT)-3 induced neurite formation and outgrowth. CRMP-1 localization shifts from axonal to somatodendritic as neurons mature, indicating roles in both early neuronal differentiation and later survival or death processes of newly generated neurons.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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