Thermo Fisher Scientific FN1 Monoclonal Antibody (OTI3F9), TrueMAB
Human FN1 단백질(aa 32-307)에 특이적인 Mouse IgG1 단클론 항체로 Western Blot 및 IHC(P) 실험에 적합. Affinity chromatography로 정제된 액상 항체이며, PBS/BSA/glycerol buffer에 보관. 세포 부착 및 이동 관련 Fibronectin 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F9 |
| Immunogen | Human recombinant protein fragment (aa 32–307 of human FN1) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight of 230–250 kDa. In connective tissues and vessels, it exists as an insoluble, cross-linked protein forming large polymers. Fibronectin is abundant during embryonic development and tissue remodeling, and also found as a soluble plasma protein.
It interacts with collagen, heparin, and cell surface receptors such as integrins, playing key roles in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis. Fibronectin expression is elevated in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The gene has three alternatively spliced regions, potentially producing up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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