Thermo Fisher Scientific CDK2 Polyclonal Antibody
CDK2 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow cytometry에 적합. 인간 반응성, 고순도 액상 형태, 2 mg/mL 농도. 연구용으로 세포 주기 관련 단백질 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 230–260 amino acids from the C-terminal region of human CDK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2260408 |
Product Specific Information
This antibody is predicted to react with bovine, hamster, mouse, rat, and Xenopus based on sequence homology.
Target Information
CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed to CyclinO. CyclinO, a specific isoform of the UNG gene, is localized exclusively in the nucleus and exhibits uracil-DNA glycosylase activity. CDK2/cyclinO levels increase during G1 phase and are regulated throughout the cell cycle. Cyclin A–cdk2 levels peak at the G1/S transition, associating with DNA during replication initiation. Rb protein serves as a substrate for cdk2–cyclin E and/or cdk2–cyclin A complexes. Cdk2 is activated and localized to the nucleus during late G1, S, and G2 phases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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