Thermo Fisher Scientific FOXK1 Polyclonal Antibody
Thermo Fisher Scientific의 FOXK1 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하며, Western blot, IHC, IP 등에 사용 가능합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, FOXK1 단백질 연구 및 대사·근육 분화 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 683 and 733 of human forkhead box K1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
FOXK1 is a transcriptional regulator involved in glucose metabolism, aerobic glycolysis, muscle cell differentiation, and autophagy. It recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can act as both activator and repressor depending on context.
Together with FOXK2, it regulates metabolic reprogramming toward aerobic glycolysis, promoting expression of glycolytic enzymes such as HK2, PFK, PKLR, and LDH, while suppressing mitochondrial pyruvate oxidation via PDK1 and PDK4.
It plays roles in gluconeogenesis during fasting, mTORC1-mediated metabolic regulation, and autophagy inhibition in skeletal muscle. FOXK1 also regulates myogenic progenitor cells, represses FOXO4 activity, and modulates Wnt/β-catenin signaling.
Additionally, it contributes to antiviral responses by binding ISRE to promote antiviral gene expression. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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