Thermo Fisher Scientific Thymidylate Synthase Monoclonal Antibody (3A7.A11)
Human thymidylate synthase를 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot, IHC, ELISA, IP에 사용 가능하며, 단백질 A로 정제된 액상 형태입니다. DNA 생합성 연구 및 항암제 반응성 분석에 적합합니다.
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Thermo Fisher Scientific Thymidylate Synthase Monoclonal Antibody (3A7.A11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5–10 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
| ELISA | 2–5 µg/mL |
| Immunoprecipitation (IP) | 5–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A7.A11 |
| Immunogen | Recombinant human thymidylate synthase produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for fluoropyrimidines, an important group of antineoplastic drugs widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS by forming a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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