Thermo Fisher Scientific Alpha-Synuclein Polyclonal Antibody
Thermo Fisher Scientific의 Alpha-Synuclein Polyclonal Antibody는 마우스 및 랫트 시료에 반응하는 기니피그 유래 항체입니다. Western blot 및 동결 절편 면역조직화학(IHC-F)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 파킨슨병 및 알츠하이머병 연구에 유용합니다.
- 카탈로그번호
- APZ-035-GPxxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Alpha-Synuclein Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:300 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)KDQMGKGEEGYPQE, corresponding to amino acid residues 97–110 of rat alpha-synuclein, Intracellular, C-terminus |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
- Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
- Avoid multiple freeze/thaw cycles.
- Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Target Information
Alpha-synuclein is a member of the synuclein family, which includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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