Thermo Fisher Scientific CD10 Recombinant Rabbit Monoclonal Antibody (7F6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides. It is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML).
Additionally, CD10 is found on breast myoepithelial cells, bile canaliculi, fibroblasts, and is highly expressed on the brush border of kidney and gut epithelial cells.
CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a gene with a >45 kb single copy. The 5′ untranslated region is alternatively spliced into four transcripts, though the coding region remains unaffected.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.