Thermo Fisher Scientific HBG2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• View 1 publication

Product Specifications

Product Specific Information

• Recommended positive controls: U87-MG
• Predicted reactivity: Rhesus Monkey (97%), Chimpanzee (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen, and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF), which is normally replaced by adult hemoglobin (HbA) at birth.
In some beta-thalassemias and related conditions, gamma chain production continues into adulthood.
The two types of gamma chains differ at residue 136, where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth.
The order of the genes in the beta-globin cluster is: 5’-epsilon -- gamma-G -- gamma-A -- delta -- beta--3’.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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