Thermo Fisher Scientific NEDD4L Polyclonal Antibody
Human NEDD4L 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NEDD4L. Recombinant protein control fragment (Product #RP-93120). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644596 |
Product Specific Information
- Immunogen sequence:
SATNSNNHLI EPQIRRPRSL SSPTVTLSAP LEGAKDSPVR RAVKDTLSNP QSPQPSPYNS PKPQHKVTQS FLPPGWEM - Highest antigen sequence identity to orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
NEDD4L is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 enzyme to target substrates. It inhibits TGF-beta signaling by promoting ubiquitination and degradation of SMAD2 and TGFR1. NEDD4L also regulates internalization and degradation of various plasma membrane channels such as ENaC, Nav1.2–1.8, Kv1.3, EAAT1, and CLC5, and promotes degradation of SGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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