Thermo Fisher Scientific KLF17 Polyclonal Antibody
Human KLF17 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태로 제공. KLF17의 전사 억제 및 EMT 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KLF17 (amino acids 195–273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643140 |
Product Specific Information
Immunogen sequence:
TVPSTEAQAV LPSMAQMLPP QDAHDLGMPP AESQSLLVLG SQDSLVSQPD SQEGPFLPEQ PGPAPQTVEK NSRPQEGTG
Antigen sequence identity:
- Mouse: 42%
- Rat: 46%
Target Information
KLF17 is a transcription repressor that binds to promoter regions of target genes to inhibit their expression. It acts as a negative regulator of epithelial-mesenchymal transition (EMT) and metastasis in breast cancer. KLF17 specifically binds to the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator, repressing its expression. It may also function as a germ cell-specific transcription factor involved in spermatid differentiation and oocyte development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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