Thermo Fisher Scientific ZC3H13 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZC3H13. Recombinant protein control fragment (Product #RP-97944). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZC3H13,uniProtId:Q5T200-1,ncbiNodeId:9606,antigenRange:63-173,antigenLength:1668,antigenImageFileName:PA5-59079_ZC3H13_Q5T200-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59079_ZC3H13_Q5T200-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649801

Product Specific Information

Immunogen sequence: PSPRGKGYSS NYRRSPERPT GDLRERMKNK RQDVDTEPQK RNTEESSSPV RKESSRGRHR EKEDIKITKE RTPESEEENV EWETNRDDSD NGDINYDYVH ELSLEMKRQK I

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 96%.

Target Information

The zinc finger CCCH domain-containing protein 13 (ZC3H13) is a 1668 amino acid protein that contains one C3H1-type zinc finger. ZC3H13 is phosphorylated upon DNA damage, most likely by ATM or ATR. Two isoforms of ZC3H13 exists as a result of alternative splicing events. The gene encoding ZC3H13 maps to chromosome 13, which contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.