Thermo Fisher Scientific Trefoil Factor 3 Monoclonal Antibody (5UCLNT3), eFluor 660, eBioscience
Mouse 및 Rat의 Trefoil Factor 3를 인식하는 단클론 항체로, eFluor 660 형광 표지 적용. 면역조직화학(IHC) 및 면역세포화학(ICC/IF)에 적합. 높은 특이성과 안정성, 형광 검출 장비 호환성 우수. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Trefoil Factor 3 Monoclonal Antibody (5UCLNT3), eFluor 660, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5UCLNT3 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574215 |
Additional Formats
Product Specific Information
The monoclonal antibody 5UCLNT3 recognizes mouse and rat Trefoil Factor 3 (TFF3).
TFF3 is a member of the trefoil family, characterized by at least one trefoil motif—a 40 amino acid domain with three conserved disulfides.
It is secreted by mucus-producing and epithelial cells in tissues such as the gastrointestinal tract, kidney, and breast.
Biological Role:
- Maintains and restores mucosal surfaces.
- Inhibits apoptosis and promotes epithelial cell survival and migration.
- Induces airway epithelial ciliated cell differentiation.
- Serves as a biomarker for kidney tubular injury.
- May contribute to breast tumor progression and dissemination.
Applications Reported:
Used for microscopy and immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.
Applications Tested:
Validated for IHC on formalin-fixed paraffin-embedded rat tissue using low pH antigen retrieval at ≤10 µg/mL.
Titrate carefully for optimal performance.
Fluorochrome Information:
eFluor™ 660 is a replacement for Alexa Fluor™ 647.
- Excitation: 633–647 nm
- Emission: 668 nm
- Laser: Red Laser
Ensure instrument compatibility for detection.
Post-manufacturing filtered through 0.2 µm.
Target Information
Trefoil peptides are protease-resistant molecules secreted throughout the gut, playing a role in mucosal healing.
They contain three intrachain disulfide bonds forming the trefoil motif (P-domain) and are clustered on human chromosome 21q22.3.
Trefoil Factor 3 (TFF3), secreted by epithelial cells of the intestines and respiratory tract, acts mainly as a disulfide-linked homodimer and promotes cell migration during mucosal repair.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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